Three British women from London, consisting of a YouTuber and her two friends, go missing from a motel in California while travelling from Los Angeles to San Francisco after posting on social media using the the hashtag #followme.
Norman Bates returns for this prequel, once more having mommy trouble. This time around he is invited to share memories of mom with a radio talk show host, but the PSYCHO fears that he may kill again for his beloved is impregnated with his child and Norman cannot let another PSYCHO loose in the civilized world.
A young psychiatrist interviews four inmates in a mental asylum to satisfy a requirement for employment. He hears stories about 1) the revenge of a murdered wife, 2) a tailor who makes a suit with some highly unusual qualities, 3) a woman who questions her sanity when it appears that her brother is conspiring against her, and 4) a man who builds tiny toy robots with lifelike human heads.
Two pretty but ditsy American girls are on a road trip through Europe. In Germany, they end up alone at night with a broken car in the woods. They search for help and find an isolated villa. The next day, they awaken to find themselves trapped in a terrifying makeshift basement hospital along with a Japanese man. An older German man identifies himself as a retired surgeon specialized in separating Siamese twins. However, his three "patients" are not about to be separated but joined together in a horrific operation. He plans to be the first person to connect people via their gastric systems. By doing so, he plans to bring to life his sick lifetime fantasy, the human centipede.
Police officer Lisa Nolan comes to Aran Island, Ireland, to take charge during a colleague's two-week holiday. Simultaneously, blood-thirsty, sea-dwelling aliens arrive at the quiet island to propagate. As dead whales wash up on shore and people start mysteriously disappearing, officers and a few locals slowly discover their peril along with one sure defense - high blood alcohol levels, which the aliens can't stomach. As a storm approaches, enabling hungry hatchlings access to the locals, an open bar kicks off a desperate bid for survival as inebriated police and friends stagger to remain cognizant long enough to thwart the alien invasion.
The San Francisco area is beset by a series of seemingly random murders without motive or pattern. The police are taunted by phone calls and letters. Could the maniac be the violent, truck driver, or the seemingly mild-mannered mailman, or even a cop?
To study a rogue planet heading for a near-miss with Earth, Prof. Elliot sets up an observatory on the foggy moors of a remote Scottish island, with his pretty daughter and Dr. Mears, a former student with a shady past. Soon after arrival of reporter John Lawrence, a ship from Planet X just happens to land near the observatory. Is the visitor (who actually looks alien) benevolent? What are Mears' real motives for trying to communicate with it?